Modified composite microspheres of hydroxyapatite and poly(lactide-co-glycolide) as an injectable scaffold

详细信息    查看全文

• 作者：Xixue Hu ; Hong Shen ; Fei Yang ; Xinjie Liang ; Shenguo Wang ; Decheng Wu
• 关键词：Hydroxyapatite ; Poly(lactide-co-glycolide) ; Composite microspheres ; Injectable scaffold ; Tissue engineering
• 刊名：Applied Surface Science
• 出版年：15 February, 2014
• 年：2014
• 卷：292
• 期：Complete
• 页码：764-772
• 全文大小：4969 K

文摘

The compound of hydroxyapatite-poly(lactide-co-glycolide) (HA-PLGA) was prepared by ionic bond between HA and PLGA. HA-PLGA was more stable than the simple physical blend of hydroxyapatite and poly(lactide-co-glycolide) (HA/PLGA). The surface of HA-PLGA microsphere fabricated by an emulsion-solvent evaporation method was rougher than that of HA/PLGA microspheres. Moreover, surface HA content of HA-PLGA microspheres was more than that of HA/PLGA microspheres. In vitro mouse OCT-1 osteoblast-like cell culture results showed that the HA-PLGA microspheres clearly promoted osteoblast attachment, proliferation and alkaline phosphatase activity. It was considered that surface rich HA component and rough surface of HA-PLGA microsphere enhanced cell growth and differentiation. The good cell affinity of the HA-PLGA microspheres indicated that they could be used as an injectable scaffold for bone tissue engineering.