Maggot debridement therapy promotes diabetic foot wound healing by up-regulating endothelial cell activity

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• 作者：Xinjuan Sun ; Jin&rsquo ; an Chen ; Jie Zhang ; Wei Wang ; Jinshan Sun ; Aiping Wang ; ^{27966509@qq.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Diabetic foot ulcers ; Maggot debridement therapy ; HUVEC ; Angiogenesis ; Wound healing
• 刊名：Journal of Diabetes and its Complications
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：30
• 期：2
• 页码：318-322
• 全文大小：810 K

文摘

To determine the role of maggot debridement therapy (MDT) on diabetic foot wound healing, we compared growth related factors in wounds before and after treatment. Furthermore, we utilized human umbilical vein endothelial cells (HUVECs) to explore responses to maggot excretions/secretions on markers of angiogenesis and proliferation. The results showed that there was neo-granulation and angiogenesis in diabetic foot wounds after MDT. Moreover, significant elevation in CD34 and CD68 levels was also observed in treated wounds. In vitro, ES increased HUVEC proliferation, improved tube formation, and increased expression of vascular endothelial growth factor receptor 2 in a dose dependent manner. These results demonstrate that MDT and maggot ES can promote diabetic foot wound healing by up-regulating endothelial cell activity.