刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:January 2017
年:2017
卷:1863
期:1
页码:129-138
全文大小:1310 K
卷排序:1863
文摘
CNS drug securinine (SCR) inhibits thioredoxin reductase (TrxR). Knockdown or pharmacological inhibition of TrxR enhances cytotoxicity of SCR. SCR promotes elevation of oxidized glutathione and thioredoxin in cells. SCR elicits oxidative stress-mediated apoptosis of HeLa cells. Targeting TrxR by SCR provides a novel mechanism for its anticancer activity.