Activation of serotonin 5-HT2C receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in morphine-dependent mice
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- 作者：Gongliang Zhanga ; d ; 1 ; gzhang@fau.edu" class="auth_mail" title="E-mail the corresponding author ; Xian Wua ; 1 ; Yong-Mei Zhangb ; 1 ; Huan Liua ; Qin Jianga ; Gang Panga ; Xinrong Taoc ; Liuyi Donga ; Robert W. Stackman Jr.d ; rstackma@fau.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Serotonin ; 5-HT2C receptor ; Morphine ; Behavioral sensitization ; Withdrawal ; Ventral tegmental area ; Nucleus accumbens ; Locus coeruleus
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：246-254
- 全文大小：1904 K
文摘
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Activation of 5-HT2CR suppresses the induction and expression of behavioral sensitization induced by morphine.
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Activation of 5-HT2CR ameliorates naloxone-precipitated withdrawal symptoms in morphine-dependent mice.
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Chronic morphine exposure increases 5-HT2CR expression in ventral tegmental area, locus coeruleus and nucleus accumbens.
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5-HT2CR may be a drug target for preventing the abuse and dependence of opioid.