Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo

详细信息    查看全文

• 作者：Fujiang Guo ; Li Feng ; Cheng Huang ; Hongxia Ding ; Xintian Zhang ; Zhaoyi Wang ; Yiming Li
• 关键词：Broussonetia papyrifera ; Prenylflavone ; Breast cancer ; Growth inhibition ; ER-¦Á36
• 刊名：Phytochemistry Letters
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：6
• 期：3
• 页码：331-336
• 全文大小：603 K

文摘

Two new prenylflavones 5,7,3¡ä,4¡ä-tetrahydroxy-3-methoxy-8-geranylflavone (1) and 5,7,3¡ä,4¡ä-tetrahydroxy-3-methoxy-8,5¡ä-diprenylflavone (2), as well as four known ones, uralenol (3), papyriflavonol A (4), broussoflavonol B (5) and broussochalcone A (6) were isolated and purified from an ethyl acetate-soluble extract of the barks of Broussonetia papyrifera. Their structures were determined with the spectroscopic methods including HR-EI-MS, 1D and 2D NMR. We found that compounds 2-6 showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro. The IC₅₀ values of compounds 2 and 5 were 4.41 and 4.19 ¦ÌM respectively after the treatment of 72 h. We also found that compounds 2 and 5 strongly down-regulated expression concentrations of estrogen receptor-¦Á (ER-¦Á) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo. Our results demonstrated that prenylflavones from B. Papyrifera exhibit potent anti-tumor activity.