Amplified voltammetric detection of miRNA from serum samples of glioma patients via combination of conducting magnetic microbeads and ferrocene-capped gold nanoparticle/streptavidin conjugates
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- 作者：Zhixuan Lua ; Hailin Tangb ; Daohong Wua ; Yonghong Xiaa ; Minghua Wuc ; Xinyao Yia ; d ; yixinyao@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hengfeng Lid ; Jianxiu Wanga ; jxiuwang@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gold nanoparticle-coated magnetic microbeads ; Hairpin DNA probe ; Target miRNA ; Fc-capped gold nanoparticle/streptavidin conjugates ; Voltammetry
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：502-507
- 全文大小：924 K
文摘
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A novel amplified voltammetric method for miRNA is proposed.
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AuNP-MMBs serve as an immobilization matrix for higher loading density.
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The enlarged surface area, good conductivity of AuNP-MMBs and the multiple Fc tags ensure high sensitivity.
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The amenability of the method for serum sample analysis was demonstrated.