Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer
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- 作者：Hanlin Zeng1 ; 2 ; Jia Qu1 ; 2 ; Nan Jin1 ; 2 ; Jun Xu1 ; Chenchu Lin1 ; Yi Chen1 ; Xinying Yang1 ; Xiang He1 ; Shuai Tang1 ; Xiaojing Lan1 ; Xiaotong Yang1 ; Ziqi Chen1 ; Min Huang1 ; mhuang@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Jian Ding1 ; jding@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Meiyu Geng1 ; 3 ; mygeng@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：histone deacetylases inhibitors ; breast cancer ; leukemia inhibitory factor receptor ; STAT3 ; BET family proteins
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：12 September 2016
- 年：2016
- 卷：30
- 期：3
- 页码：459-473
- 全文大小：4494 K
文摘
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HDAC inhibitors transcriptionally activate LIFR in breast cancer cells
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BRD4 is required for LIFR upregulation provoked by HDAC inhibition
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LIFR-JAK1-STAT3 signaling limits response to HDAC inhibition
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JAK or BRD4 inhibition augments efficacy of HDAC inhibitors in breast cancer