Extracellular histones induce tissue factor expression in vascular endothelial cells via TLR and activation of NF-κB and AP-1
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- 作者：Xinyu Yanga ; Lin Lia ; Jin Liua ; Ben Lva ; Fangping Chena ; b ; hope058@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tissue factor ; Histones ; Thrombosis
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：211-218
- 全文大小：765 K
文摘
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Our data show histones enhanced TF expression and activity in vascular endothelial cells and macrophages.
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Histone-induced tissue factor expression may be a previously unrecognized link between inflammation and thrombosis.
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Histones-induced TF expression is mediated by the activation of the TLR4, TLR2 receptors.
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We identified NF-κB and AP-1 as important transcription factors involved in histones-induced TF expression.