Dynamin-related protein inhibitor downregulates reactive oxygen species levels to indirectly suppress high glucose-induced hyperproliferation of vascular smooth muscle cells
详细信息 查看全文
- 作者：Alimujiang Maimaitijiang ; Xinyu Zhuang ; Xiaofei Jiang ; Yong Li ; 11211220031@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitochondrial dynamics ; Mfn2 ; Drp1 ; Mdivi-1 ; ROS ; Vascular smooth muscle cells
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 March 2016
- 年：2016
- 卷：471
- 期：4
- 页码：474-478
- 全文大小：824 K
文摘
- •
Mdivi-1 inhibits VSMC proliferation by lowering ROS level in high-glucose condition.
- •
ROS may be able to induce mitochondrial fission through Drp1 regulation.
- •
Mdivi-1 can suppress the sensitivity of Drp1 to ROS.