Eicosapentaenoic acid abolishes inhibition of insulin-induced mTOR phosphorylation by LPS via PTP1B downregulation in skeletal muscle

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• 作者：Hong-Kui Wei^a ; ¹ ; Zhao Deng^a ; ¹ ; Shu-Zhong Jiang^a ; Tong-Xing Song^a ; Yuan-Fei Zhou^a ; Jian Peng^a ; ^{pengjian@mail.hzau.edu.cn} ; Ya-Xiong Tao^b ; ^{taoyaxi@auburn.edu}
• 关键词：Eicosapentaenoic acid ; Lipopolysaccharide ; Myotubes ; Insulin ; Mammalian target of rapamycin
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：116-125
• 全文大小：1667 K
• 卷排序：439

文摘

EPA abolished LPS-induced deficiency in insulin-induced mTOR photophosphorylation in skeletal muscle. EPA inhibited LPS-induced AP1 and NF-κB activation and PTP1B transcription in skeletal muscle. Decreased LPS-induced PTP1B expression contributed to the effect of EPA on LPS-induced deficiency in insulin signaling.