Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway

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• 作者：Taiyuan Li ; Dongning Liu ; Xiong Lei ; Qunguang Jiang ; ^{JiangQG168@gmail.com}
• 关键词：Par3L ; CRISPR/Cas ; Colorectal cancer ; AMPK pathway ; Lkb1
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1037-1041
• 全文大小：908 K
• 卷排序：482

文摘

Par3L knockout using the CRISPR/Cas system induces apoptosis in colorectal cancer cells. Par3L interacts with Lkb1 and regulates the activity of AMPK signaling cascade. Par3L knockout cells are more sensitive to treatment of different chemotherapy drugs and irradiation.