Endoplasmic reticulum stress and disturbed calcium homeostasis are involved in copper-induced alteration in hepatic lipid metabolism in yellow catfish Pelteobagrus fulvidraco
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- 作者：Yu-Feng Songa ; b ; Zhi Luoa ; b ; 1 ; luozhi99@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; luozhi99@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; zl493@cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Li-Han Zhanga ; b ; Christer Hogstrandc ; Ya-Xiong Pana ; b
- 关键词：Pelteobagrus fulvidraco ; Copper ; Endoplasmic reticulum stress ; Calcium homeostasis ; Lipid metabolism
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：2443-2453
- 全文大小：2165 K
文摘
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ER stress contributes to lipid accumulation in Cu-evoked change of lipid metabolism.
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The release of Ca2+ from the ER contributed to dysregulation of lipid metabolism.
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Cu-induced alteration in lipid metabolism was suppressed through the attenuation of ER stress.