Testing the Effect of Internal Genes Derived from a Wild-Bird-Origin H9N2 Influenza A Virus on the Pathogenicity of an A/H7N9 Virus
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- 作者：Wen Su1 ; 6 ; Chengmin Wang1 ; Jing Luo1 ; Yuliang Zhao1 ; Yan Wu2 ; Lin Chen1 ; 6 ; Na Zhao1 ; 6 ; Meng Li1 ; 6 ; Chao Xing1 ; Huimin Liu1 ; Hong Zhang1 ; Yung-fu Chang4 ; Tianxian Li5 ; Hua Ding2 ; Xiufeng Wan3 ; Hongxuan He1 ; hehx@ioz.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：22 September 2015
- 年：2015
- 卷：12
- 期：11
- 页码：1831-1841
- 全文大小：3312 K
文摘
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Diverse wild bird H9N2 influenza virus genes elevate the virulence of an H7N9 virus
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An H7N9 virus bearing wild-bird H9N2 virus PB1 gene (r2) kills mice and chickens
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The reassortant virus r2 is not transmitted by respiratory droplets in guinea pigs
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The reassortant r2 acquires airborne mammalian transmissibility by substitutions