Real-time elastography with a novel quantitative technology for assessment of liver fibrosis in chronic hepatitis B

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• 作者：Juan Wang ^{jjz.1986@gmail.com} ; Long Guo ^{longguo601@gmail.com} ; Xiuying Shi ^{jingjiandiaolong@sina.com} ; Wenqian Pan ^{holy_dragon601@163.com} ; Yunfei Bai ^{yfb1970@sina.com} ; Hong Ai ; ^{hongai163@gmail.com}
• 关键词：Noninvasive diagnosis ; Liver fibrosis stage ; Real-time elastography ; Chronic hepatitis B
• 刊名：European Journal of Radiology
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：81
• 期：1
• 页码：e31-e36
• 全文大小：546 K

文摘

Background

The accurate evaluation of liver fibrosis stage is important in determining the treatment strategy. The limitations of percutaneous liver biopsy as the gold standard are obvious for invasion. Real-time elastography with conventional ultrasound probes and a new quantitative technology for diffuse histological lesion is a novel approach for staging of liver fibrosis.

Purpose

This study aimed to evaluate the value of real-time tissue elastography with a new quantitative technology for the assessment of liver fibrosis stage.

Materials and methods

Real-time elastography was performed in 55 patients with liver fibrosis and chronic hepatitis B and in 20 healthy volunteers. Eleven parameters for every patient in colorcode image obtained from the real-time elastography were analyzed with principal components analysis. We analyzed the correlation between elasticity index and liver fibrosis stage and the accuracy of real-time elastography for liver fibrosis staging. Additionally, aspartate transaminase-to-platelet ratio index was also included in the analysis.

Results

The Spearman's correlation coefficient between the elasticity index and the histologic fibrosis stage was 0.81, which is highly significant (p < 0.001). The areas under receiver operating characteristic curves indicating diagnostic accuracy were 0.93 (F ?#xA0;F1, p < 0.001) for the diagnosis of liver fibrosis, 0.92 (F ?#xA0;F2, p < 0.001), 0.84 (F ?#xA0;F3, p < 0.05) and 0.66 (F = F4, p > 0.05), respectively.

Conclusions

Real-time elastography with a new quantitative technology for diffuse histological lesion is a new and promising sonography-based noninvasive method for the assessment of liver fibrosis in patients with chronic hepatitis B.