Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats
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- 作者：Rachel B. Scheinerta ; b ; Aditya Asokanb ; Asha Ranic ; d ; Ashok Kumarc ; d ; Thomas C. Fosterc ; d ; foster1@ufl.edu" class="auth_mail" title="E-mail the corresponding author ; Brandi K. Ormerodb ; c ; d ; bormerod@bme.ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aging ; Inflammation ; Neuroinflammation ; Memory ; Hippocampus ; Water maze ; xMAP technology ; Cytokines ; Chemokines
- 刊名：Brain, Behavior, and Immunity
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：49
- 期：Complete
- 页码：216-232
- 全文大小：1350 K
文摘
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Similar numbers of middle-aged and aged rats exhibited memory probe impairments.
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Some serum, hippocampal and cortical analyte levels quantified changed across lifespan.
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Candidate serum biomarkers predicted spatial and non-spatial scores in aging rats.
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Cortical biomarkers generally predicted non-spatial behavioral scores in aging rats.
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Hippocampal biomarkers predicted spatial scores in aging rats.