XPC deficiency is related to APE1 and OGG1 expression and function
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- 作者：Julliane Tamara Araú ; jo de Meloa ; Ana Rafaela de Souza Timoteoa ; Tirzah Braz Petta Lajusa ; Juliana Alves Brandã ; oa ; Nadja Cristhina de Souza-Pintob ; Carlos Frederico Martins Menckc ; Anna Campalansd ; J. Pablo Radicellad ; Alexandre Teixeira Vessonic ; e ; Alysson Renato Muotrie ; Lucymara Fassarella Agnez-Limaa ; lfagnez@ufrnet.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oxidative stress ; XPC ; APE1 ; OGG1 ; DNA damage ; DNA repair
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2016
- 出版时间：February-March 2016
- 年：2016
- 卷：784-785
- 期：Complete
- 页码：25-33
- 全文大小：1746 K
文摘
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XPC deficient cells show reduction of APE1 and OGG1 mRNA basal levels.
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XPC cells show a delay in activation of APE1 and absence of OGG1 activation under oxidative stress.
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XPC interacts physically with APE1 but not with OGG1.
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XPC is required for OGG1 activity.