A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin
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- 作者：Dora Grecua ; b ; Victor Paul Raj Irudayaraja ; b ; d ; e ; f ; Juan Martinez-Sanza ; b ; c ; Jean-Maurice Malletd ; e ; f ; Liliane Assairia ; b ; liliane.assairi@orange.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：C-HsCen2 ; human centrin 2C-terminal domain ; Sfi1 ; suppressor of fermentation-induced loss of stress resistance protein1 ; XPC ; xeroderma pigmentosum group C protein ; Sac3 ; is the central component of the transcription and mRNA export (TREX-2) complex ; ITC ; isothermal titration calorimetry ; CD ; circular dichroism
- 刊名：Peptides
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：77-86
- 全文大小：2044 K
文摘
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Centrin binds to Sfi1 and XPC.
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Centrin-binding sites of Sfi1 and XPC have reversed sequence.
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XPC-derived d-peptides show reduced binding capacity to centrin.
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Sfi1-derived d-peptides do not bind to centrin.
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XPC-derived d-peptides could be use to inhibit centrin function