MOG infusion blocked effector T cell recruitment to the CNS and protected mice from EAE.

Mature CD11b⁺ cells preferentially recruited MOG-specific effector T cells.

Mature APCs were enriched in the CNS rather than in the spleen, attracting effector T cells to the CNS to initiate disease.

MOG infusion induced splenic APC maturation, trapped MOG-specific CD4⁺ T cells in the periphery by APC-T cell interaction.