Several novel functionalized chitosan-based nanohydrogels were synthesized.
These nanohydrogels show different soluble property at a wide range of pH.
5-Fluorouracil (5-FU), a chemotherapy drug, was loaded into the nanohydrogels.
These nanohydrogels showed a consecutive release of 5-FU at different conditions.
Possible mechanisms of CS-based nanohydrogels and 5-FU loading were investigated.