Synthesis of chitosan-based nanohydrogels for loading and release of 5-fluorouracil
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- 作者：Songfeng Liua ; Jianhui Zhangb ; Xuejun Cuia ; Yachen Guoa ; Xiaoming Zhangb ; ; Wang Hongyana ; b ; wanghongyan505@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nanohydrogels ; pH range ; Thermal-sensitive ; Release behavior
- 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：490
- 期：Complete
- 页码：91-97
- 全文大小：1961 K
文摘
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Several novel functionalized chitosan-based nanohydrogels were synthesized.
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These nanohydrogels show different soluble property at a wide range of pH.
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5-Fluorouracil (5-FU), a chemotherapy drug, was loaded into the nanohydrogels.
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These nanohydrogels showed a consecutive release of 5-FU at different conditions.
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Possible mechanisms of CS-based nanohydrogels and 5-FU loading were investigated.