MMGZ01, an anti-DLL4 monoclonal antibody, promotes nonfunctional vessels and inhibits breast tumor growth
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- 作者：Zhuobin Xu1 ; Zegen Wang1 ; 2 ; Xuelian Jia ; Luxuan Wang ; Zhiguo Chen3 ; Shijing Wang ; Min Wang ; minwang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Juan Zhang ; juancpu@126.com" class="auth_mail" title="E-mail the corresponding author ; Min Wu ; mickeywu2001@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DLL4 monoclonal antibody ; Notch ; Breast cancer ; Nonfunctional vessels ; Antitumor ; Angiogenesis
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：372
- 期：1
- 页码：118-127
- 全文大小：3249 K
文摘
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We generated a novel monoclonal antibody MMGZ01 that specifically binds to DLL4 with high affinity.
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MMGZ01 disrupted the interaction between DLL4 and Notch1 leading to an increase in nonfunctional vasculature.
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MMGZ01 inhibited breast tumor growth effectively by multiple mechanisms in vivo.
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MMGZ01 reduced BCSC population and induced the reversal of EMT either alone or in combination with docetaxel.
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MMGZ01 provides a new approach for breast cancer therapy.