Risk factors for metastasis to para-aortic lymph nodes in gastric cancer: A single institution study in China

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• 作者：Li Wang ; MD^a ; ^b ; Han Liang ; MD^a ; ^b ; ^{tjlianghan022@sohu.com} ; Xiaona Wang ; MD^a ; ^b ; Fangxuan Li ; MD^a ; ^b ; Xuewei Ding ; MD^a ; ^b ; Jingyu Deng ; MD^a ; ^b
• 关键词：Gastric neoplasm ; Para-aortic lymph node ; Metastasis ; Risk factors
• 刊名：Journal of Surgical Research
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：179
• 期：1
• 页码：54-59
• 全文大小：173 K

文摘

Background

Para-aortic lymph node (PAN) dissection is performed in some gastric cancer patients with extensive lymph node involvement. However, there is no consensus on selection of patients that will benefit from this high risk dissection. This study was to identify risk factors for PAN metastasis in gastric cancer.

Materials and methods

A total of 174 patients with gastric cancer who underwent D2 lymphadenectomy plus para-aortic nodal dissection in Tianjin Medical University Cancer Institute and Hospital from January 2001 to December 2010 were enrolled in the study. The association between clinicopathologic factors and para-aortic nodal invasion was analyzed.

Results

Forty-seven patients (27.0 % ) had PAN metastases. Pathologic N stage was a significant risk factor for PAN metastasis after adjusting for other factors. A significant difference was shown in the proportion of PAN metastases between the N0/N1 group and N2/N3 group (6.2 % versus 45.2 % , P < 0.001, OR?=?12.620). Lymph node station 9 showed a much higher odds ratio with PAN metastases than other routinely retrieved stations.

Conclusion

N stage and perigastric nodal status were important and independent risk factors for PAN metastasis, which may be useful for identifying patients at high risk of PAN metastasis who could benefit from PAN dissection.