UFLC–ESI–MS/MS utilized for PK study of six Saikosaponins following oral administration of Bupleurum Dropping Pills.
The assay simultaneously determines six Saikosaponins components in rat plasma.
LLOQs of these six active components are 0.2 ng/ml.
This is the first pharmacokinetic study of multiple active constituent absorbed into plasma after oral administration of Bupleurum Dropping Pills in rats.