A mitochondria-targetable near-infrared fluorescent probe for imaging nitroxyl (HNO) in living cells
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- 作者：Xueyun Gonga ; b ; Xiao-Feng Yanga ; xfyang@nwu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yaogang Zhongc ; Yanhong Chena ; Zheng Lic
- 关键词：Nitroxyl ; Merocyanine ; 2-(Diphenylphosphino)benzoate ; Fluorescent probe ; Bioimaging
- 刊名：Dyes and Pigments
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：131
- 期：Complete
- 页码：24-32
- 全文大小：1414 K
文摘
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A near-infrared fluorescent probe for nitroxyl has been constructed.
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The proposed probe is constructed by using 2-(diphenylphosphino)benzoyl group as the recognition moiety.
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The proposed probe is highly selective toward nitroxyl over other biologically relevant reactive species.
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Preliminary experiments proved that the probe is suitable for visualizing HNO in mitochondria of live cells.