Biodegradable and thermosensitive polyaspartamide derivatives bearing aromatic structures

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• 作者：Yingying Ma ; Xulin Jiang ; ^{xljiang@whu.edu.cn" class="auth_mail} ; Renxi Zhuo
• 关键词：Aromatic structures ; Biomaterials ; Hydrolytic degradation ; Polymers ; Polyaspartamide derivatives ; Stimulus-responsive
• 刊名：Materials Letters
• 出版年：15 April, 2014
• 年：2014
• 卷：121
• 期：Complete
• 页码：78-80
• 全文大小：427 K

文摘

Due to most drugs possessing hydrophobic phenyl-like structures, aromatic moiety could provide high drug-loading capacity and stability in drug delivery systems. In this work, biodegradable and thermosensitive polyaspartamide derivatives bearing pendant aromatic structures (phe-g-PHPA) are designed and synthesized via aminolysis of poly(succinimide) with 5-aminopentanol and introduction of aromatic functionalities to the side chains. All the five phe-g-PHPA polymers are soluble in water at low temperature (4 掳C) and show thermosensitive behavior. The thermoresponsive behavior of the resulted phe-g-PHPA polymers can be tuned by adjusting the graft copolymer composition and partial removal of pendant aromatic moieties due to the hydrolytic degradation, which can be used for controlled drug release. The nanoparticles self-assembled from the biodegradable phe-g-PHPA polymers by a quick heating process were not stable under the physiological condition and hydrophilic long PEG chain will be introduced for drug delivery application.