Multilayer sodium alginate beads with porous core containing chitosan based nanoparticles for oral delivery of anticancer drug
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- 作者：Jing Lia ; Changqing Jiangb ; Xuqian Langa ; Ming Konga ; Xiaojie Chenga ; Ya Liua ; Chao Fenga ; 1 ; fengchao@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiguang Chena ; 1 ; xgchen@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan ; Porous-beads ; Internal crosslinking ; External crosslinking ; Sustained release
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：1-8
- 全文大小：1833 K
文摘
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Multilayer beads with and without porous were prepared by ionic gelation.
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Porous-beads showed high entrapment efficiency and delayed drug release in GI tract.
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The oral bioavailability of DOX was significantly promoted by porous-beads.