Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells
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- 作者：Alfred Xuyang Sun1 ; 2 ; 3 ; 8 ; alfred_xy_sun@nni.com.sg" class="auth_mail" title="E-mail the corresponding author ; Qiang Yuan4 ; 5 ; 8 ; Shawn Tan4 ; 5 ; Yixin Xiao4 ; Danlei Wang4 ; Audrey Tze Ting Khoo4 ; Levena Sani1 ; Hoang-Dai Tran2 ; Paul Kim4 ; Yong Seng Chiew4 ; Kea Joo Lee6 ; Yi-Chun Yen4 ; Huck Hui Ng2 ; 5 ; Bing Lim1 ; 9 ; Hyunsoo Shawn Je4 ; 7 ; shawn.je@duke-nus.edu.sg" class="auth_mail" title="E-mail the corresponding author
- 关键词：direct conversion ; GABA ; human pluripotent stem cells ; interneuron ; synapse
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：16
- 期：7
- 页码：1942-1953
- 全文大小：4341 K
文摘
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We identify factors that directly induce GABAergic neurons (iGNs) from hPSCs
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iGNs express telencephalic interneuron markers and the subtype marker SST
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iGNs functionally mature, release GABA, and generate synaptic networks in vitro
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iGNs integrate into host synaptic circuits in vivo