T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production
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- 作者：Hiroyuki Sumi ; hiroyuki.sumi@takeda.com" class="auth_mail" title="E-mail the corresponding author ; Masakazu Inazuka ; Kentaro Hashimoto ; Tomoyasu Ishikawa ; Sei Yoshida ; Masato Yabuki ; masato.yabuki@takeda.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：IAP antagonist ; T-3256336 ; TNFα ; cIAP
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：14 October 2016
- 年：2016
- 卷：479
- 期：2
- 页码：179-185
- 全文大小：1989 K
文摘
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The baseline TNFα expression correlates with the sensitivity to T-3256336.
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T-3256336 drastically increases plasma TNFα and other cytokines in mice.
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TNFα neutralizing antibody attenuates the antitumor efficacy of T-3256336.
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An efficacy of IAP antagonist in vivo depends on the systemic TNFα production.