Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development

详细信息    查看全文

• 作者：Xing Li^a ; ^b ; Katherine A. Campbell^c ; ^d ; ^f ; Sherri M. Biendarra^c ; Andre Terzic^c ; ^d ; ^e ; ^g ; Timothy J. Nelson^c ; ^d ; ^e ; ^f ; ^h ; ⁱ ; ^{Nelson.Timothy@mayo.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Induced pluripotent stem cell ; Cardiac development ; Nos3 knockout ; Disease modeling ; Microarray analysis
• 刊名：Genomics Data
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：7
• 期：Complete
• 页码：129-130
• 全文大小：605 K

文摘

The dataset includes microarray data (Affymetrix Mouse Genome 430 2.0 Array) from WT and Nos3^−/− mouse embryonic heart ventricular tissues at 14.5 days post coitum (E14.5), induced pluripotent stem cells (iPSCs) derived from WT and Nos3^−/− mouse tail tip fibroblasts, iPSC-differentiated cardiomyocytes at Day 11, and mouse embryonic stem cells (mESCs) and differentiated cardiomyocytes as positive controls for mouse iPSC differentiation. Both <em>in uteroem> (using embryonic heart tissues) and <em>in vitroem> (using iPSCs and differentiated cells) microarray datasets were deposited to the NCBI Gene Expression Omnibus (GEO) database. The deposited data in GEO include raw microarray data, metadata for sample source information, experimental design, sample and data processing, and gene expression matrix. The data are available under GEO Access Number GSE69317 (GSE69315 for tissue sample microarray data, GSE69316 for iPSCs microarray data, erref" data-locatorType="url" data-locatorKey="http://www-ncbi-nlm-nih-gov.library.gcu.edu:2048/geo/query/acc.cgi?acc=">http://www-ncbi-nlm-nih-gov.library.gcu.edu:2048/geo/query/acc.cgi?acc= GSE69317).