Synthesis of N-substituted-2-aminobenzothiazoles using nano copper oxide as a recyclable catalyst under ligand-free conditions, in reusable PEG-400 medium

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• 作者：Satish Gaddam ; Harshavardhan Reddy Kasireddy ; Karnakar Konkala ; Ramesh Katla ; Nageswar Yadavalli Venkata Durga ; ^{dryvdnageswar@gmail.com" class="auth_mail}
• 关键词：2-Aminobenzothiazoles ; 2-Iodoanilines ; Isothiocyanates ; CuO nanoparticles ; Recyclability ; PEG-400
• 刊名：Chinese Chemical Letters
• 出版年：May 2014
• 年：2014
• 卷：25
• 期：5
• 页码：732-736
• 全文大小：2320 K

文摘

A simple and practical method for the synthesis of N-substituted-2-aminobenzothiazoles via a cross-coupling reaction of 2-iodo anilines with isothiocyanates is envisaged using nano copper oxide as a recyclable catalyst and Cs₂CO₃ as a base in PEG-400, as a bio-degradable, reusable, inexpensive and non-toxic reaction medium, under ligand-free conditions. The present tandem process underlines environmental acceptability to access a wide range of N-substituted-2-aminobenzothiazoles in good to excellent yields.