A tryptophan derivative TD-26 attenuates thrombus formation by inhibiting both PI3K/Akt signaling and binding of fibrinogen to integrin 伪IIb尾3
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- 作者：Yahui Chena ; 1 ; Ying Wanga ; 1 ; Zhouling Xieb ; Xin Mingc ; Zhiyu Lib ; zhiyuli@263.net" class="auth_mail" title="E-mail the corresponding author ; Yi Konga ; yikong668@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Platelet aggregation ; Platelet adhesion ; Integrin 伪IIb尾3 ; PI3K/Akt signaling
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：25 September 2015
- 年：2015
- 卷：465
- 期：3
- 页码：516-522
- 全文大小：885 K
文摘
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TD-26 is a novel synthetic tryptophan derivative.
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TD-26 inhibited both PI3K/Akt signaling and the binding of fibrinogen to integrin 伪IIb尾3.
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TD-26 showed potent antithrombotic effect while without obvious bleeding risk.