Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives

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• 作者：Zhongjin Yang¹ ; Beijia Kuang¹ ; Ning Kang ; Yahui Ding ; Weizhi Ge ; Lihui Lian ; Yuan Gao ; Yuqing Wei ; Yue Chen ; ^{yuechen@nankai.edu.cn} ; Quan Zhang ; ^{zhangquan612@163.com}
• 关键词：Parthenolide ; Acute myeloid leukemia ; Apoptosis ; KG1a ; Synthesis
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：296-304
• 全文大小：784 K
• 卷排序：127

文摘

Compound 6j is 8.7 folds more potent than that of PTL for KG1a cells. The selectivity index of 6j between KG1a and normal cells was 30.8. Preliminary study revealed that compound 6j could induce apoptosis of KG1a cells.