Agonist-mediated activation of Bombyx mori diapause hormone receptor signals to extracellular signal-regulated kinases 1 and 2 through Gq-PLC-PKC-dependent cascade
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- 作者：Xue Jianga ; Jingwen Yangc ; Zhangfei Shena ; Yajie Chena ; Liangen Shia ; ; Naiming Zhoub ; znm2000@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diapause ; Neuropeptide ; G protein-coupled receptor ; Signaling ; Extracellular signal-regulated kinase ; Protein kinase C ; Phosphorylation
- 刊名：Insect Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：78-88
- 全文大小：1974 K
文摘
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Bombyx DHR is activated by DH via a Gq protein-dependent Pathway.
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Activated BmDHR induces ERK1/2 phosphorylation in a dose- and time-dependent manner.
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BmDHR triggers ERK1/2 activation through Gq-dependent cascade.
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Gβγ and PI3K are involved in BmDHR-mediated activation of ERK1/2.
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EGFR and Src are unlikely to implicate in BmDHR-induced ERK1/2 phosphorylation.