High-sensitivity cardiac troponin T in essential hypertension

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• 作者：Yukihito  ; Sato MD ; PhD ; FJCC  ; ;   ; ^{cardioys@kuhp.kyoto-u.ac.jp} ; Erika  ; Yamamoto MD ; Takuma  ; Sawa MD ; Keizo  ; Toda ; Tomoko  ; Hara ; Toshiaki  ; Iwasaki ; Hisayoshi  ; Fujiwara MD ; PhD ; FJCC ; Yoshiki  ; Takatsu MD ; PhD
• 关键词：Heart failure ; Hypertension ; Biomarker ; High-sensitivity troponin ; Myocyte injury
• 刊名：Journal of Cardiology
• 出版年：2011
• 出版时间：November 2011
• 年：2011
• 卷：58
• 期：3
• 页码：226-231
• 全文大小：301 K

文摘

Summary

Background

Myocyte injury might be involved in the progression of essential hypertension (EHT) toward heart failure (HF). However, in the absence of high-sensitivity (hs) assay, cardiac troponin T (TnT) in EHT has not been measurable.

Methods and results

We studied 236 consecutive ambulatory patients (mean age = 65.5 years; 110 men) with treated EHT (mean systolic blood pressure = 134.3 mmHg, mean serum N-terminal pro-B-type natriuretic peptide = 86.6 pg/ml) for mean 65.6 months. Patients with a history of HF were excluded. Single and multiple variable analyses were performed in search of clinical correlates of elevated hs-TnT (?.003 ng/ml).

Serum concentration of hs-TnT was ?.003 ng/ml (mean = 0.008 ng/ml) in 184 patients. By single variable analysis, age, uric acid, log-transformed N-terminal pro-B-type natriuretic peptide, brachial-ankle pulse wave velocity, Cornell electrocardiographic (ECG) voltage, and number of antihypertensive medications were associated with log-transformed hs-TnT, while hemoglobin and estimated glomerular filtration rate (eGFR) were inversely correlated with log-transformed hs-TnT. By multivariate analysis, age, eGFR and Cornell voltage were independent correlates of log-transformed hs-TnT, even after adjustment for clinical backgrounds including known prognostic biomarkers of EHT.

Conclusions

hs-TnT was ?.003 ng/ml in 78 % of patients presenting with treated EHT and independently correlated with age, renal function, and ECG voltage of hypertrophy.