Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy
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- 作者：Eisuke Sakakibara ; Ryu Takizawa ; Yukika Nishimura ; Shingo Kawasaki ; Yoshihiro Satomura ; Akihide Kinoshita ; Shinsuke Koike ; Kohei Marumo ; Masaru Kinou ; Mamoru Tochigi ; Nao Nishida ; Katsushi Tokunaga ; Satoshi Eguchi ; Syudo Yamasaki ; Tatsunobu Natsubori ; Norichika Iwashiro ; Hideyuki Inoue ; Yosuke Takano ; Kunio Takei ; Motomu Suga ; Hidenori Yamasue ; et al.
- 关键词：DZ ; dizygotic ; FIQ ; full-scale intelligence quotient ; LFT ; Letter Fluency Task ; MZ ; monozygotic ; NIRS ; near-infrared spectroscopy ; rCBV ; regional cerebral blood volume ; SES ; socioeconomic status ; SNP ; single nucleotide polymorphism ; WAIS-R ; Wechsler Adult Intelligence Scale-Revised ; [oxy-Hb] ; concentration of oxyhemoglobin ; [deoxy-Hb] ; concentration of deoxyhemoglobin
- 刊名：NeuroImage
- 出版年：15 January, 2014
- 年：2014
- 卷：85
- 期：part_P1
- 页码：508-517
- 全文大小：1893 K
文摘
Near-infrared spectroscopy (NIRS) studies have reported that prefrontal hemodynamic dysfunction during executive function tasks may be a promising biomarker of psychiatric disorders, because its portability and noninvasiveness allow easy measurements in clinical settings. Here, we investigated the degree to which prefrontal NIRS signals are genetically determined. Using a 52-channel NIRS system, we monitored the oxy-hemoglobin (oxy-Hb) signal changes in 38 adult pairs of right-handed monozygotic (MZ) twins and 13 pairs of same-sex right-handed dizygotic (DZ) twins during a letter version of the verbal fluency task. Heritability was estimated based on a classical twin paradigm using structured equation modeling. Significant genetic influences were estimated in the right dorsolateral prefrontal cortex and left frontal pole. The degrees of heritability were 66% and 75% in the variances, respectively. This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders.