Phospholipase A2 enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis
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- 作者：Soledad Bustilloa ; solebustillo@yahoo.es" class="auth_mail" title="E-mail the corresponding author ; soledadb@exa.unne.edu.ar" class="auth_mail" title="E-mail the corresponding author ; Marí ; a Emilia Garcí ; a-Denegria ; Carolina Gaya ; Andrea C. Van de Veldea ; Ofelia Acostaa ; Yamileth Angulob ; Bruno Lomonteb ; José ; Marí ; a Gutié ; rrezb ; Laura Leivaa
- 关键词：Metalloproteinase ; Phospholipase A2 ; Endothelial cells ; Snake venoms ; Synergism
- 刊名：Chemico-Biological Interactions
- 出版年：2015
- 出版时间：5 October 2015
- 年：2015
- 卷：240
- 期：Complete
- 页码：30-36
- 全文大小：855 K
文摘
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The acidic PLA2 significantly enhances the detaching effect of the SVMP.
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Baltergin and BaSpIIRP4 PLA2 act synergistically on this toxic effect.
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Neutralization of the venom with specific antibodies confirmed the synergism.
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Inhibition of enzymatic activity of the PLA2 with p-BPB did not affect the synergism.
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Synergism occurs even when using trace amounts of PLA2.