Effects of anti-CD70 mAb on Theiler's murine encephalomyelitis virus-induced demyelinaiting disease
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- 作者：Satoshi Yanagisawa ; Naoya Takeichi ; Tomoki Kaneyama ; Hideo Yagita ; Syun'ichiro Taniguchi ; Byung S. Kim ; Chang-Sung Koh
- 关键词：CD70 ; Theiler's murine encephalomyelitis virus ; Multiple sclerosis ; Costimulatory molecules ; Demyelinating disease
- 刊名：Brain Research
- 出版年：2010
- 出版时间：4 March 2010
- 年：2010
- 卷：1317
- 期：Complete
- 页码：236-245
- 全文大小：1853 K
文摘
Ligation of CD27, a member of the tumor necrosis factor (TNF) receptor family, by its ligand CD70 is thought to be important in T cell activation, expansion and survival, B cell activation, and NK cell activation. We examined the role of CD70 in Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) mice. Blocking of CD70 in effector phase by anti-CD70 monoclonal antibody (mAb) suppressed the development of TMEV-IDD. The number of IFN-γ- or TNF-α-producing cells in the spleen and mRNA levels of IFN-γ and TNF-α in spinal cord were decreased in mice treated with anti-CD70 mAb at the effector phase. In contrast, treatment with anti-CD70 mAb in induction phase failed to reduce these responses, compared to nonspecific IgG-treated control mice. These data suggest that CD70 is critically involved in the pathogenesis of TMEV-IDD and that antibodies against CD70 could be a novel therapeutic approach in the clinical treatment of demyelinating diseases such as human multiple sclerosis.