Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis
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- 作者：Satoshi Ohtaa ; ; Kenji Tagoa ; Megumi Funakoshi-Tagob ; Jitsuhiro Matsugia ; Ken Yanagisawaa
- 关键词：IL-33 ; Cytokine ; Ras ; Transformation ; Cyclin D1 ; Protein synthesis
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：1025-1036
- 全文大小：1338 K
文摘
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Oncogenic Ras induces the expression of IL-33.
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Intracellular IL-33 is required for oncogenic Ras-provoked cellular transformation.
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IL-33 contributes to the oncogenic Ras-induced protein synthesis of cyclin D1.