Immunohistochemical Detection of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor in Canine Vascular Endothelial Tumours

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• 作者：Sh. Anwarup>&lowast ; up>up> ; up>up>&dagger ; up> ; T. Yanaiup>&dagger ; up> ; H. Sakaiup>&dagger ; up>up> ; up>up>&Dagger ; up>up> ; up>up>shiroki@gifu-u.ac.jp" class="auth_mail" title="E-mail the corresponding authorup>
• 关键词：dog ; haemangioma ; haemangiosarcoma ; urokinase plasminogen activator
• 刊名：Journal of Comparative Pathology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：153
• 期：4
• 页码：278-282
• 全文大小：1072 K

文摘

Immunohistochemistry was used to assess the expression of urokinase plasminogen activator (uPA) and uPA receptor (uPAR) in 57 canine primary haemangiosarcomas (HSAs), 26 canine cutaneous haemangiomas (HAs) and in control sections of canine cutaneous granulation tissue. The correlation between uPA/uPAR expression and the Ki67 labelling index (LI) was estimated in the HSA and HA tissues. uPA was expressed by 73.2% and 75.0% of splenic HSAs and non-splenic HSAs, respectively. All HSA tissues tested expressed uPAR. Expression of both molecules was significantly higher in HSAs than in cutaneous HAs (3.8% for uPA and 30.7% for uPAR). The average Ki67 LI of the uPAup>+up>/uPARup>+up> HSAs was significantly higher than that of uPAup>&minus;up>/uPARup>+up> HSAs and HA tissues (mean &plusmn; SDs 32.8 &plusmn; 15.3, 15.2 &plusmn; 7.2 and 2.1 &plusmn; 0.7, respectively; P <0.05). These results suggest that uPA and uPAR play a significant role in the malignant proliferation of canine HSA, regardless of the primary origin of the tumour.