A panel of promoter methylation markers for invasive and noninvasive early detection of NSCLC using a quantum dots-based FRET approach
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- 作者：Yunfei Maa ; b ; 1 ; Yanan Baia ; 1 ; Hailei Maoc ; Qunying Hongd ; Dawei Yangd ; Honglian Zhanga ; Fangming Liua ; Zhenhua Wua ; Qinghui Jina ; Hongbo Zhoua ; Jian Caoe ; Jianlong Zhaoa ; Xinhua Zhongb ; zhongxh@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hongju Maoa ; hjmao@mail.sim.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Promoter methylation ; Early detection ; NSCLC ; Bronchial brushing ; Quantum dots ; FRET
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：641-648
- 全文大小：1086 K
文摘
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We established a new QDs-based FRET nanosensor technique for the detection of DNA methylation.
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The method was able to identify both invasive and noninvasive NSCLC samples from control cases.
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The method is proven to be a convenient, sensitive, cost-efficient and reliable method.
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The method is expected to be a potential tool for noninvasive early clinical diagnosis of cancers.