A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy
详细信息 查看全文
- 作者：Guo Chen1 ; 4 ; Zhe Han1 ; 4 ; Du Feng1 ; 2 ; Yanfang Chen1 ; Linbo Chen1 ; Hao Wu3 ; Li Huang3 ; Changqian Zhou1 ; Xiangyu Cai1 ; Changying Fu1 ; Liangwei Duan1 ; Xiaohui Wang3 ; Lei Liu3 ; Xinqi Liu1 ; Yuequan Shen1 ; Yushan Zhu1 ; zhuys@nankai.edu.cn" class="auth_mail ; Quan Chen1 ; 3 ; chenq@ioz.ac.cn" class="auth_mail
- 刊名：Molecular Cell
- 出版年：8 May 2014
- 年：2014
- 卷：54
- 期：3
- 页码：362-377
- 全文大小：4755 K
文摘
- •
FUNDC1 dephosphorylation at Ser-13 activates mitophagy
- •
PGAM5 and CK2 regulate the reversible phosphorylation of FUNDC1
- •
Knockdown of PGAM5 abrogates receptor-mediated mitophagy
- •
CK2 and Src kinase functionally cooperate to regulate FUNDC1-mediated mitophagy