Expression of YY1 and CP2c was investigated in mouse gonocytes and germ cells using tissue immunohistochemical and immunofluorescence analyses.
YY1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis.
The expression of YY1 and CP2c shows spermatogenic cycle stage specificity.
Reciprocal expression of YY1 and CP2c might be important for regulating stemness and differentiation of spermatogonial stem cells.