STAT3 stimulates adipogenic stem cell proliferation and cooperates with HMGA2 during the early stage of differentiation to promote adipogenesis

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• 作者：Yanyan Yuan¹ ; ^{1511101190@nbu.edu.cn} ; Yang Xi¹ ; ^{xiyang@nbu.edu.cn} ; Jiayi Chen ^{1047395416@qq.com} ; Pan Zhu ^{1119300591@qq.com} ; Jinyu Kang ^{924528232@qq.com} ; Zuquan Zou ^{zouzuquan@nbu.edu.cn} ; Fuyan Wang ^{wangfuyan@nbu.edu.cn} ; Shizhong Bu ; ^{bushizhong@nbu.edu.cn}
• 关键词：STAT3 ; HMGA2 ; Adipogenesis ; Proliferation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1360-1366
• 全文大小：1387 K
• 卷排序：482

文摘

We discovered an activation of STAT3 during the early differentiation stage of mouse 3T3-L1 preadipocytes. Stat3 knockdown using siRNA blocked cell cycle progression of both preadipoctes and early differentiating cells. Accumulation of lipid droplets was inhibited by Stat3 knockdown. STAT3 protein co-localized with HMGA2, which was reported to promote adipogenesis in a previous study.