Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice

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• 作者：Morais ; L.C.S.L. ; Barbosa-Filho ; J.M. ; Almeida ; R.N.
• 关键词：Ocotea duckei ; Lauraceae ; Reticuline ; Benzylisoquinoline alkaloid ; Central nervous system ; Neuroleptic
• 刊名：Journal of Ethnopharmacology
• 出版年：1998
• 出版时间：August, 1998
• 年：1998
• 卷：62
• 期：1
• 页码：57-61
• 全文大小：77.9 K

文摘

Neuropharmacological studies were carried out with reticuline, a benzylisoquinoline alkaloid, isolated from Ocotea duckei Vattimo. It was found that reticuline (50–100 mg/kg i.p.) produced alteration of behaviour pattern, prolongation of pentobarbital-induced sleep, reduction in motor coordination and d-amphetamine-induced hypermotility and suppression of the conditioned avoidance response. These observations suggest that reticuline possesses potent central nervous system depressant action. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0378-8741(98)00044-0 Publication Type: Article ISSN: 0378-8741 Cited by:

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Footnotes:

1. This paper is based on the MSc project of I.G.S., LTF/UFPB, Brazil.