In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii

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• 作者：Jae Yeon Kim ; Hyo Jin Lim ; Da Yeon Lee ; Ji Sun Kim ; Do Hee Kim ; Hwa Jin Lee ; Hee Doo Kim ; Raok Jeon ; Jae-Ha Ryu
• 关键词：Magnolia fargesii ; Nitric oxide ; Prostaglandin E₂ ; Microglia
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2009
• 出版时间：1 February 2009
• 年：2009
• 卷：19
• 期：3
• 页码：937-940
• 全文大小：232 K

文摘

The overproduction of nitric oxide (NO) and prostaglandin E₂ (PGE₂) causes neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE₂ and the expression of respective enzyme iNOS and COX-2 through the suppression of I-κB-α degradation and nuclear translocation of p65 subunit of NF-κB.