Study of circulating IgG antibodies to peptide antigens derived from BIRC5 and MYC in cervical cancer
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- 作者：Yangchun Xua ; 1 ; Yonglong Jina ; 1 ; Linlin Liua ; Xuan Zhanga ; zhangxuankj@163.com" class="auth_mail" title="E-mail the corresponding author ; Yubing Chena ; ybchend@163.com" class="auth_mail" title="E-mail the corresponding author ; Jun Weib
- 关键词：AUC ; area under ROC curve ; BIRC5 ; baculoviral IAP repeat-containing protein 5 isoform 2 ; HPV ; human papillomavirus ; IgG ; immunoglobulin G ; MYC ; myc proto-oncogene protein ; ROC ; receiver operating characteristic curve ; SBI ; specific binding index ; SCC ; squamous cell carcinoma ; TAAs ; tumor-associated antigens
- 刊名：FEBS Open Bio
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：5
- 期：Complete
- 页码：198-201
- 全文大小：408 K
文摘
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Autoantibodies to BIRC5 and MYC were measured in cervical cancer patients and a control group.
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There was a significant difference in circulating levels of these autoantibodies in the patient and control groups.
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ROC analysis suggests that anti-BIRC5 IgG has a higher sensitivity than anti-MYC IgG.
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Anti-BIRC5 IgG could serve as a biomarker for the early diagnosis of cervical cancer.