In situ hybridization chain reaction mediated ultrasensitive enzyme-free and conjugation-free electrochemcial genosensor for BRCA-1 gene in complex matrices
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- 作者：Hui Yanga ; yanghui@haust.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yang Gaoa ; Siqi Wangb ; You Qinc ; Lu Xub ; Dan Jinb ; jimyin_126@126.com" class="auth_mail" title="E-mail the corresponding author ; Fan Yangb ; yangf2013@hbtcm.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Guo-Jun Zhangb
- 关键词：Genosensor ; Electrochemistry ; Hybridization chain reaction ; Signal amplification ; BRCA-1 gene
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：450-455
- 全文大小：1521 K
文摘
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We develop an enzyme-free and conjugation-free electrochemical genosensor.
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A bifunctional initiator probe can serve as a versatile trigger.
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This genosensor achieves an ultrahigh sensitivity up to 1 aM.
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This sensor was employed directly in human serum with minimal signal degradation.