Determination and pharmacokinetics of chinensinaphthol methyl ether in rat urine by a sensitive and specific UFLC-ESI-MS/MS method
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- 作者：Jia&rsquo ; an Qina ; b ; Jiaoyang Luob ; Hongzheng Zhaob ; Shanshan Zhangb ; Xingguo Zhanga ; zxg332@126.com" class="auth_mail" title="E-mail the corresponding author ; Meihua Yangb ; yangmeihua15@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chinensinaphthol methyl ether ; UFLC-ESI-MS/MS ; Determination ; Urine pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：1033-1034
- 期：Complete
- 页码：311-316
- 全文大小：825 K
文摘
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A UFLC-ESI-MS/MS method was applied to determine CME in rat urine.
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A reliable and simple sample preparation method was optimized.
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The concentration-time and accumulation excretion curve was delineated.
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The pharmacokinetics of CME in rat urine after single oral dose was investigated.