Identification of TgAtg8-TgAtg3 interaction in Toxoplasma gondii
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- 作者：Di Chena ; Jiaxin Linb ; Yangyang Liub ; Xiangzhi Lic ; Gaozhi Chend ; Qianqian Huae ; Qinqin Nief ; Xin Hub ; gail529@163.com" class="auth_mail" title="E-mail the corresponding author ; Feng Tang ; tanfengsong@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Toxoplasma gondii ; Autophagy ; Atg8 ; Atg3 ; Surface plasmon resonance ; Protein&ndash ; protein interaction
- 刊名：Acta Tropica
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：153
- 期：Complete
- 页码：79-85
- 全文大小：1453 K
文摘
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TgAtg8–TgAtg3 interaction occurs in Toxoplasma gondii.
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The TgAtg8 can bind directly TgAtg3 in vitro.
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There is higher affinity between TgAtg8 and TgAtg3.
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TgAtg8 possesses the conserved structure to interact with other TgAtg containing AIM.
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TgAtg3 contains core E2 enzymatic activity structure and a truncated handle region.