Inhibition of CD147 expression promotes chemosensitivity in HNSCC cells by deactivating MAPK/ERK signaling pathway

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• 作者：Chao Ma ; Jianqi Wang ; Longkun Fan ; Yanjun Guo ; ^{wallton117@qq.com}
• 关键词：HNSCC ; head and neck squamous cell carcinoma ; MDR ; multidrug-resistance ; MAPK ; mitogen-activated protein kinase ; ERK ; extracellular signal-regulated kinases ; PMA ; phorbol 12-myristate 13-acetate ; 5-FU ; 5-fluorouracil ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; ABCG2 ; ATP-binding cassette transporter G2
• 刊名：Experimental and Molecular Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：102
• 期：1
• 页码：59-64
• 全文大小：847 K
• 卷排序：102

文摘

CD147 is highly expressed in HNSCC tissues and Tu686 cell line. Upregulated CD147 expression in HNSCC cells was related to multidrug chemoresistance. Lack of CD147 expression increases chemosensitivity by deactivating MAPK/ERK pathway. Activation of MAPK/ERK increases multidrug chemoresistance in Tu686 cell line.