Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation
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- 作者：Sivapriya Kailasan Vanaja<sup>1sup> ; Ashley J. Russo<sup>1sup> ; Bharat Behl<sup>1sup> ; Ishita Banerjee<sup>1sup> ; Maya Yankova<sup>2sup> ; Sachin D. Deshmukh<sup>3sup> ; Vijay A.K. Rathinam<sup>1sup><sup> ; sup><sup>rathinam@uchc.edu" class="auth_mail" title="E-mail the corresponding authorsup>
- 刊名：Cell
- 出版年：2016
- 出版时间：19 May 2016
- 年：2016
- 卷：165
- 期：5
- 页码：1106-1119
- 全文大小：4095 K
文摘
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OMVs secreted by bacteria enable intracellular LPS localization
OMVs activate caspase-11-mediated cytosolic LPS sensing
OMVs enter the cells by endocytosis, and LPS accesses cytosol from early endosomes
OMVs are essential for the activation of caspase-11 during bacterial infections.